Drug-induced hyperthermia

Drug-induced fever is a state wherein the administration of drugs intended to help a patient causes a fever. The drug may interfere with heat dissipation peripherally, increase the rate of metabolism, evoke a cellular or humoral immune response, mimic endogenous pyrogen, or damage tissues.

Triggers

Directly caused by the drug, e.g. lamictal, progesterone, or chemotherapeutics causing tumor necrosis
Possible side effect of stimulants and entactogens (e.g. cocaine, MDMA, methamphetamine, PMA, 4-MTA)
As an adverse reaction to drugs, e.g. antibiotics or sulfa drugs.
After drug discontinuation, e.g. heroin or fentanyl withdrawal
Neuroleptic Malignant Syndrome; rare, life-threatening hyperpyrexia caused by antidopaminergic drugs (mostly antipsychotics)
Serotonin Syndrome; excessive serotonergic activity due usually to combined use of serotonergic drugs (e.g. antidepressants, stimulants, triptans)
5HT2A agonists, e.g. psilocybin or LSD

External links

Tabor PA (June 1986). "Drug-induced fever". Drug Intell Clin Pharm 20 (6): 413–20. PMID 3522163.

Symptoms and signs: general / constitutional (R50–R61, 780.6–780.9)

Temperature	heat: Fever (Fever of unknown origin, Drug-induced fever, Postoperative fever) • Hyperhidrosis (e.g., Sleep Hyperhidrosis; "Sweating") • Hyperpyrexia • Hyperthermia cold: Chills

Aches/Pains	Headache • Chronic pain • Cancer pain

Malaise and fatigue	Atrophy (e.g., Muscle Atrophy) • Debility (or Asthenia) • Lassitude • Lethargy • Muscle tremors • Tenderness

Miscellaneous	Flu-Like Symptoms